It is necessary for normal endochondral ossification, the process by which the growing skeleton is formed. Mice lacking this gene often exhibit dwarfism and craniofacial abnormalities due to impaired chondrocyte proliferation.
A breakthrough study published in Nature discovered that a "gain-of-function" mutation in the miR-140 gene leads to a severe, novel autosomal dominant human skeletal dysplasia. 🔬 Function in Cancer and Therapeutics 140 РђРЅРѕРЅСЃ
In many malignancies—including breast, lung, prostate, and gastrointestinal cancers—miR-140 is significantly downregulated. It typically acts as a tumor suppressor by inhibiting cell proliferation, invasion, and metastasis while encouraging cell death (apoptosis). It is necessary for normal endochondral ossification, the
Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix. 🔬 Function in Cancer and Therapeutics In many
Because its levels fluctuate heavily depending on the presence of tumors, tracking miR-140 expression quantities in tissue is actively researched as a way to predict clinical outcomes and survival rates in patients with neoplasia.