: Also features carboxylic dimers but is located on crystallographic inversion centers.
: These findings suggest that the manufacturing environment (heat and solvent choice) directly determines which form of the drug is produced. 4. Conclusion
The ability to characterize these moderately complex substances from powder diffraction data allows for a better understanding of their crystal chemistry. For Acitretin (54757-46-9), the transition between dimers and catamers represents a significant shift in molecular arrangement that must be monitored during the production of oral retinoid therapies.
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: The standard material deposited in the European Pharmacopoeia. It consists of four crystallographically independent molecules arranged in pairs via hydrogen-bonded carboxylic dimers ( ResearchGate ).
The stability of these forms is sensitive to temperature and pressure:
