Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis
Research indicates that AKT isoforms are not functionally redundant: File: AKT_collection_compressed_2022-11-20.zip ...
Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI alter the PH domain structure
We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers File: AKT_collection_compressed_2022-11-20.zip ...