The main question the study is powered to answer (e.g., "Does this drug lower blood pressure?").
Neither the patient nor the researcher knows.As a trialist, your job is to maintain this "seal" throughout the study. Once the blind is broken, the statistical weight of your findings drops significantly. 3. Choosing the Right Endpoints Fundamental Concepts for New Clinical Trialists
What does "success" look like? You must define this before the first patient is enrolled. The main question the study is powered to answer (e