G8634.mp4 -

-S) is a thiophosphate analog of guanosine triphosphate (GTP). The key difference is the substitution of a sulfur atom for an oxygen atom on the terminal phosphate group (γ-phosphate). G8634-1MG CAS Number: 94825-44-2 Formula: Molecular Weight: 562.98 Appearance: White to off-white powder Assay: 2. Biological Mechanism of Action The primary utility of GTP- -S lies in its resistance to hydrolysis by GTPases.

Solutions are very unstable; they must be prepared immediately prior to use.

Technical Profile: Guanosine 5′-[γ-thio]triphosphate (GTP- -S) - G8634 1. Introduction and Chemical Nature Guanosine 5′-[γ-thio]triphosphate (GTP- g8634.mp4

-S), a non-hydrolyzable analog of GTP. It is widely used in biochemical research as a .

While G-proteins hydrolyze GTP to GDP to turn "off" signaling, they cannot efficiently hydrolyze GTP- -S) is a thiophosphate analog of guanosine triphosphate

Requires a dust mask (N95), eyeshields, and gloves. WGK: 3. Source References: Sigma-Aldrich Product Detail PubMed - Cell Signaling Studies Sigma-Aldrich SDS

Used to protect proteins from proteolytic degradation. 4. Stability and Handling The product is sensitive and requires careful handling. Storage: -20°C. Biological Mechanism of Action The primary utility of

Involved in studies of membrane trafficking, including oocyte and mammalian cell patch-clamp experiments.