Experiments have shown its capability to study both morphology (structural) and neuronal activity (functional) in mouse brains. 4. Implementation and Data Handling
The system described in the 2026 publications (often referred to as the ULTRA system) provides an unprecedented combination of field-of-view (FOV) and depth. Multi-scale in vivo neuronal imaging.
Optimized for in vivo studies, involving anaesthetized animals to maintain consistency.
The system produces large, dense 3D datasets requiring advanced denoising, sometimes utilizing "zero-shot learning" methods to process weak fluorescence signals without pre-training on existing data. Summary of Performance (2026) Capability Field of View Imaging Depth Spatial Range Volume Coverage Resolution Cellular resolution
This system enables the integration of multi-scale information, bridging the gap between broad cortical coverage and deep, high-resolution structural studies, providing a versatile platform for exploring large-scale neuronal circuitry. To make this guide more tailored,g., LabVIEW 2020)? control? Specific neuroscience applications and results?
The system sequences through Zernike modes to compensate for aberrations, with optimization processes sometimes completing in minutes, tailored for high-speed scanning (e.g., 133 Hz for ROI).
