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In biological research, is a protein that plays a dual role, acting as both an activator and a repressor of gene expression. It is fundamental to normal development but is also heavily implicated in various diseases, particularly cancer. Biological Functions and Mechanisms
: It is critical for embryogenesis, neurogenesis, and B-cell differentiation. Complete loss of YY1 in mice is often lethal during early development.
: YY1 recruits chromatin modifiers like histone deacetylases (HDACs) for repression or p300 for activation. It also plays a role in 3D chromatin organization. Clinical Significance
: YY1 can initiate, activate, or repress transcription depending on the cellular context and its interacting cofactors.
In biological research, is a protein that plays a dual role, acting as both an activator and a repressor of gene expression. It is fundamental to normal development but is also heavily implicated in various diseases, particularly cancer. Biological Functions and Mechanisms
: It is critical for embryogenesis, neurogenesis, and B-cell differentiation. Complete loss of YY1 in mice is often lethal during early development.
: YY1 recruits chromatin modifiers like histone deacetylases (HDACs) for repression or p300 for activation. It also plays a role in 3D chromatin organization. Clinical Significance
: YY1 can initiate, activate, or repress transcription depending on the cellular context and its interacting cofactors.
